11月3日，24直播网报道，周三拂晓时分，欧洲冠军联赛第四轮赛事中，曼联队将在他们的主场老特拉福德球场与罗马队展开激烈对决。
In their history of encounters, Manchester United and AS Roma have faced each other on eight prior occasions, with United holding a slight advantage, having secured five victories, one draw, and two defeats. Despite Roma's triumph in the second leg of the UEFA Europa League semi-finals in May 2021, with a 3-2 victory, United ultimately advanced to the next round with an aggregate score of 8-5.
在老特拉福德球场，曼联与罗马的交锋中取得了四场胜利，这一成就成为了他们在欧洲主要赛事中的主场不败纪录之一，与安德莱赫特的对决同样以四战全胜告终。值得关注的是，现任曼联主教练卡里克在球员时期六次在欧冠赛场上遭遇罗马，尤其是在2007年，他在曼联以7-1的比分大胜罗马的四分之一决赛次回合中攻入两球。